反应详情

7.1 g of methyl 2-oxocyclopentane-1-carboxylate and 9.6 g of 4-chlorobenz-amidine hydrochloride were introduced into 50 ml of methanol. 5.6 g of potassium tert-butoxide were added with stirring. The reaction mixture was stirred under reflux for 4 hours and then poured onto ice water. The crystalline product was filtered off with suction, washed with water and recrystallized from dimethylformamide.

1. stirringThe reaction mixture was stirred
2. temperatureunder reflux for 4 hours
3. additionpoured onto ice water
4. filtrationThe crystalline product was filtered off with suction
5. washwashed with water
6. customrecrystallized from dimethylformamide