Cyclopentylamine → 2-(4-Chlorophenyl)-4-cyclopentylamino-6,7-dihydro-5H-cyclopenta[d]pyrimidine

HRID 722014Notes

Reaction equation

HRID 722014 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]=[C:10](Cl)[C:11]3[CH2:16][CH2:15][CH2:14][C:12]=3[N:13]=2)=[CH:4][CH:3]=1.[CH:18]1([NH2:23])[CH2:22][CH2:21][CH2:20][CH2:19]1.CN1CCCC1=O>O>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]=[C:10]([NH:23][CH:18]3[CH2:22][CH2:21][CH2:20][CH2:19]3)[C:11]3[CH2:16][CH2:15][CH2:14][C:12]=3[N:13]=2)=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 2906CyclopentylamineHCID 13387N-methyl-2-pyrrolidoneHCID 111614002-(4-Chlorophenyl)-4-chloro-6,7-dihydro-5H-cyclopenta[d]pyrimidine

Product 1

HCID 111627962-(4-Chlorophenyl)-4-cyclopentylamino-6,7-dihydro-5H-cyclopenta[d]pyrimidine

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

0.265 g of 2-(4-chlorophenyl)-4-chloro-6,7-dihydro-5H-cyclopenta[d]pyrimidine, 0.4 g of cyclopentylamine and 1 ml of N-methylpyrrolidone were heated to 130° C. in an oil bath. After 5 hours, the mixture was diluted with 20 ml of water and stirred at room temperature. The precipitated product was filtered off with suction, washed with water and dried in vacuo at 40° C.

Workup

  1. filtrationThe precipitated product was filtered off with suction
  2. washwashed with water
  3. customdried in vacuo at 40° C.

Sources & evidence

ORD record
ord-e91134c80d244ec7ae69ad308f76d387
Source dataset
uspto-grants-2006_11
Patent number
US07138398B2

Reaction notes

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