HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(4-Methyl-1,4-diazepan-1-yl)aniline → 6-Bromo-3-[4-(4-methyl[1,4]diazepan-1-yl)phenyl]-3H-thieno[3,2-d]pyrimidin-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(4-Methyl-1,4-diazepan-1-yl)aniline | HCID 13007951 | — |
| Reactant | 5-Bromo-3-(dimethylaminomethyleneamino)thiophene-2-carboxylic acid methyl ester | HCID 60027040 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | 6-Bromo-3-[4-(4-methyl[1,4]diazepan-1-yl)phenyl]-3H-thieno[3,2-d]pyrimidin-4-one | HCID 68975672 | — |
Reaction Steps
5-Bromo-3-(dimethylaminomethyleneamino)thiophene-2-carboxylic acid methyl ester was reacted with 4-(4-methyl[1,4]diazepan-1-yl)phenylamine by method A1 with addition of isopropanol in addition. The product with the molecular weight of 419.34 (C18H19BrN4OS) was obtained in this way; MS (EST): 419, 421 (N+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08828991B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-336c691c159541829614b2b356ea7e53 |
| Source note | uspto-grants-2014_09 |