4-(4-Methyl-1,4-diazepan-1-yl)aniline → 6-Bromo-3-[4-(4-methyl[1,4]diazepan-1-yl)phenyl]-3H-thieno[3,2-d]pyrimidin-4-one

HRID 72202Notes

Reaction equation

HRID 72202 reaction equation
CO[C:3]([C:5]1[S:6][C:7]([Br:15])=[CH:8][C:9]=1[N:10]=[CH:11][N:12]([CH3:14])C)=[O:4].[CH3:16][N:17]1[CH2:23][CH2:22][CH2:21][N:20]([C:24]2[CH:29]=[CH:28]C(N)=[CH:26][CH:25]=2)[CH2:19][CH2:18]1>C(O)(C)C>[Br:15][C:7]1[S:6][C:5]2[C:3](=[O:4])[N:12]([C:14]3[CH:28]=[CH:29][C:24]([N:20]4[CH2:21][CH2:22][CH2:23][N:17]([CH3:16])[CH2:18][CH2:19]4)=[CH:25][CH:26]=3)[CH:11]=[N:10][C:9]=2[CH:8]=1

Participants

4

Reactant 2

HCID 130079514-(4-Methyl-1,4-diazepan-1-yl)anilineHCID 600270405-Bromo-3-(dimethylaminomethyleneamino)thiophene-2-carboxylic acid methyl ester

Product 1

HCID 689756726-Bromo-3-[4-(4-methyl[1,4]diazepan-1-yl)phenyl]-3H-thieno[3,2-d]pyrimidin-4-one

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

5-Bromo-3-(dimethylaminomethyleneamino)thiophene-2-carboxylic acid methyl ester was reacted with 4-(4-methyl[1,4]diazepan-1-yl)phenylamine by method A1 with addition of isopropanol in addition. The product with the molecular weight of 419.34 (C18H19BrN4OS) was obtained in this way; MS (EST): 419, 421 (N+H+).

Workup

  1. customThe product with the molecular weight of 419.34 (C18H19BrN4OS) was obtained in this way

Sources & evidence

ORD record
ord-336c691c159541829614b2b356ea7e53
Source dataset
uspto-grants-2014_09
Patent number
US08828991B2

Reaction notes

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