4-(4-Methyl-1,4-diazepan-1-yl)aniline → 6-Cyclopropylethynyl-3-[4-(4-methyl[1,4]diazepan-1-yl)phenyl]-3H-thieno[3,2-d]pyrimidin-4-one

HRID 72203Notes

Reaction equation

HRID 72203 reaction equation
CO[C:3]([C:5]1[S:6][C:7]([C:15]#[C:16][CH:17]2[CH2:19][CH2:18]2)=[CH:8][C:9]=1[N:10]=[CH:11][N:12]([CH3:14])C)=[O:4].[CH3:20][N:21]1[CH2:27][CH2:26][CH2:25][N:24]([C:28]2[CH:33]=[CH:32]C(N)=[CH:30][CH:29]=2)[CH2:23][CH2:22]1>>[CH:17]1([C:16]#[C:15][C:7]2[S:6][C:5]3[C:3](=[O:4])[N:12]([C:14]4[CH:32]=[CH:33][C:28]([N:24]5[CH2:25][CH2:26][CH2:27][N:21]([CH3:20])[CH2:22][CH2:23]5)=[CH:29][CH:30]=4)[CH:11]=[N:10][C:9]=3[CH:8]=2)[CH2:18][CH2:19]1

Participants

3

Reactant 2

HCID 130079514-(4-Methyl-1,4-diazepan-1-yl)anilineHCID 689443485-Cyclopropylethynyl-3-(dimethylaminomethyleneamino)thiophene-2-carboxylic acid methyl ester

Product 1

HCID 576253186-Cyclopropylethynyl-3-[4-(4-methyl[1,4]diazepan-1-yl)phenyl]-3H-thieno[3,2-d]pyrimidin-4-one

Procedure

5-Cyclopropylethynyl-3-(dimethylaminomethyleneamino)thiophene-2-carboxylic acid methyl ester was reacted with 4-(4-methyl[1,4]diazepan-1-yl)phenylamine by method A1. The product with the molecular weight of 404.53 (C23H24N4OS) was obtained in this way; MS (ESI): 405 (M+H+).

Workup

  1. customThe product with the molecular weight of 404.53 (C23H24N4OS) was obtained in this way

Sources & evidence

ORD record
ord-f2d3ec1f9e6d4b2c8647a68d55357d04
Source dataset
uspto-grants-2014_09
Patent number
US08828991B2

Reaction notes

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