反应详情

Tin chloride (11.8 g) was added to a solution of 5-cyclopropylethynyl-3-nitrothiophene-2-carboxylic acid methyl ester (6.26 g) in ethanol (250 ml), and the reaction mixture was heated to reflux for 4 h. The solvent was then removed in vacuo, and the residue was taken up again in ethyl acetate and washed with sat. Rochelle salt solution. The organic phase was dried over sodium sulfate and the solvent was removed in vacuo. The product with the molecular weight of 221.27 (C11H11NO2S) was obtained in this way; MS (ESI): 222 (M+H+).

1. temperaturethe reaction mixture was heated
2. temperatureto reflux for 4 h
3. customThe solvent was then removed in vacuo
4. washwashed with sat. Rochelle salt solution
5. dry with materialThe organic phase was dried over sodium sulfate
6. customthe solvent was removed in vacuo
7. customThe product with the molecular weight of 221.27 (C11H11NO2S) was obtained in this way