Cyclopropylacetylene → 5-Cyclopropylethynyl-3-nitrothiophene-2-carboxylic acid methyl ester

HRID 72205Notes

Reaction equation

HRID 72205 reaction equation
[CH3:1][O:2][C:3]([C:5]1[S:6][C:7](Br)=[CH:8][C:9]=1[N+:10]([O-:12])=[O:11])=[O:4].[C:14]([CH:16]1[CH2:18][CH2:17]1)#[CH:15]>>[CH3:1][O:2][C:3]([C:5]1[S:6][C:7]([C:15]#[C:14][CH:16]2[CH2:18][CH2:17]2)=[CH:8][C:9]=1[N+:10]([O-:12])=[O:11])=[O:4]

Participants

3

Reactant 2

HCID 138823CyclopropylacetyleneHCID 57618723Methyl 5-bromo-3-nitrothiophene-2-carboxylate

Product 1

HCID 689420965-Cyclopropylethynyl-3-nitrothiophene-2-carboxylic acid methyl ester

Procedure

5-Bromo-3-nitrothiophene-2-carboxylic acid methyl ester was reacted with ethynylcyclopropane by method Q. The product with the molecular weight of 251.26 (C11H9NO4S) was obtained in this way; MS (ESI): 252 (M+H+).

Workup

  1. customThe product with the molecular weight of 251.26 (C11H9NO4S) was obtained in this way

Sources & evidence

ORD record
ord-e16440d8f017426788ed5f78febb4410
Source dataset
uspto-grants-2014_09
Patent number
US08828991B2

Reaction notes

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