2-Amino-3-nitro-5-cyclohexylmethyl-pyridine → 2-Amino-3-nitro-5-cyclohexylmethyl-pyridine

HRID 722055Notes

Reaction equation

HRID 722055 reaction equation
[NH2:1][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][C:5]([CH2:11][CH:12]2[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]2)=[CH:4][N:3]=1>ClCCl.CO>[NH2:1][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][C:5]([CH2:11][CH:12]2[CH2:13][CH2:14][CH2:15][CH2:16][CH2:17]2)=[CH:4][N:3]=1.[NH2:1][C:2]1[C:7]([NH2:8])=[CH:6][C:5]([CH2:11][CH:12]2[CH2:13][CH2:14][CH2:15][CH2:16][CH2:17]2)=[CH:4][N:3]=1

Participants

4

Reactant 1

HCID 218827232-Amino-3-nitro-5-cyclohexylmethyl-pyridine

Product 2

HCID 218827232-Amino-3-nitro-5-cyclohexylmethyl-pyridineHCID 21882760HCID 21882760, compound

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

Similiarly to Example C1, the hydrogenation of 0.365 g of 2-amino-3-nitro-5-cyclohexylmethyl-pyridine (starting material E2) gives 0.29 g of the title compound as a dark powder (after chromatography with dichloromethane/methanol 99:1). The mass spectrum shows the molecular peak MH+ at 205 Da.

Sources & evidence

ORD record
ord-f82e2bbfa90046c5b5d2ce8b79de1e5f
Source dataset
uspto-grants-2006_11
Patent number
US07138399B2

Reaction notes

Loading…