HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → 8-Bromo-7H-purine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Purine | HCID 1044 | — |
| Reactant | Bromine | HCID 24408 | — |
| Reactant | HCID 178418247 | HCID 178418247 | — |
| Solvent | HCID 86598190 | HCID 86598190 | — |
| Product | 8-Bromo-7H-purine | HCID 21883050 | — |
Reaction Steps
A solution of purine in MeOH/THF/acetate buffer (1N in each AcOH and AcONa) was treated with Br2 (1.3-equiv. 1M in CHCl3) at room temperature (r.t.) for 16 h. Evaporation, work-up (EtOAc), drying (MgSO4) and flash chromatography afforded the desired 8-bromopurine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07138401B2 |
| Source dataset | uspto-grants-2006_11 |
| ORD ID | ord-5bbf77858b6c4cb38cc5ed2a65e278d9 |
| Source note | uspto-grants-2006_11 |