HRID722082

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID176

Acetic Acid

C2H4O2

HCID1044

Purine

C5H4N4

HCID24408

Bromine

Br2

HCID178418247

未命名化合物

PRODUCTS

生成物

HCID21883050

8-Bromo-7H-purine

C5H3BrN4

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID86598190

未命名化合物

PROCEDURE

实验过程

A solution of purine in MeOH/THF/acetate buffer (1N in each AcOH and AcONa) was treated with Br2 (1.3-equiv. 1M in CHCl3) at room temperature (r.t.) for 16 h. Evaporation, work-up (EtOAc), drying (MgSO4) and flash chromatography afforded the desired 8-bromopurine.

WORKUP

后处理

customEvaporation, work-up (EtOAc)
dry with materialdrying (MgSO4) and flash chromatography