HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Anhydride → 2-Pyridinemethanol, 2-acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | 2-Methylpyridine 1-oxide | HCID 13602 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 2-Pyridinemethanol, 2-acetate | HCID 13881 | — |
Reaction Steps
A solution of the 2-methyl pyridine N-oxide (1.0 mmol) in acetic anhydride (5 mmol) was heated to reflux for 0.5 h. Work-up (EtOAc), drying (MgSO4), evaporation and purification by preparative TLC or flash chromatography afforded the 2-(acetoxymethyl)pyridine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07138401B2 |
| Source dataset | uspto-grants-2006_11 |
| ORD ID | ord-46b932fbdc8540ac87584522c6800eb6 |
| Source note | uspto-grants-2006_11 |