p-Fluoronitrobenzene → tert-Butyl 4-(4-nitrophenyl)-1,4-diazepane-1-carboxylate

HRID 72209Notes

Reaction equation

HRID 72209 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:14][CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].F[C:16]1[CH:21]=[CH:20][C:19]([N+:22]([O-:24])=[O:23])=[CH:18][CH:17]=1>>[C:1]([O:5][C:6]([N:8]1[CH2:14][CH2:13][CH2:12][N:11]([C:16]2[CH:21]=[CH:20][C:19]([N+:22]([O-:24])=[O:23])=[CH:18][CH:17]=2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 9590p-FluoronitrobenzeneHCID 2756058Tert-butyl 1,4-diazepane-1-carboxylate

Product 1

HCID 18008978tert-Butyl 4-(4-nitrophenyl)-1,4-diazepane-1-carboxylate

Procedure

[1,4]Diazepane-1-carboxylic acid tert-butyl ester was reacted with 1-Fluoro-4-nitro-benzene at 60° C. by method D. The product with the molecular weight of 321.38 (C16H23N3O4) was obtained in this way; MS (ESI): 322 (M+H+).

Workup

  1. customThe product with the molecular weight of 321.38 (C16H23N3O4) was obtained in this way

Sources & evidence

ORD record
ord-852f1a1370e14c52b49b720a861f560f
Source dataset
uspto-grants-2014_09
Patent number
US08828991B2

Reaction notes

Loading…