Benzoyl chloride, 3,4,5-trimethoxy- → HCID 21883046, compound

HRID 722098Notes

Reaction equation

HRID 722098 reaction equation
[Cl:1][C:2]1[N:10]=[C:9]([NH2:11])[N:8]=[C:7]2[C:3]=1[N:4]=[CH:5][NH:6]2.[CH3:12][O:13][C:14]1[CH:15]=[C:16]([CH:20]=[C:21]([O:25][CH3:26])[C:22]=1[O:23][CH3:24])[C:17](Cl)=[O:18]>N1C=CC=CC=1>[NH2:11][C:9]1[N:8]=[C:7]2[C:3]([N:4]=[CH:5][N:6]2[C:17]([C:16]2[CH:20]=[C:21]([O:25][CH3:26])[C:22]([O:23][CH3:24])=[C:14]([O:13][CH3:12])[CH:15]=2)=[O:18])=[C:2]([Cl:1])[N:10]=1

Participants

4

Reactant 2

HCID 78282Benzoyl chloride, 3,4,5-trimethoxy-HCID 1785084356-chloro-1H-purin-2-amine

Product 1

HCID 21883046HCID 21883046, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

A solution of 6-chloro-9H-purin-2-ylamine in pyridine was treated with 3,4,5-trimethoxybenzoyl chloride at r.t. for 2 h. Work-up and purification by preparative TLC (EtOAc:hexane 1:1) gave the title compound. HPLC Rt: 5.305 min. 1H-NMR (CDCl3): δ 8.24 (s, 1H), 7.13 (s, 2H), 5.36 (s, 2H), 3.99 (s, 3H), 3.88 (s, 6H).

Workup

  1. custompurification by preparative TLC (EtOAc:hexane 1:1)

Sources & evidence

ORD record
ord-05786054ba9b4f23889aae1fe9db821f
Source dataset
uspto-grants-2006_11
Patent number
US07138401B2

Reaction notes

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