Potassium Carbonate → 6-Chloro-9-(3,4,5-trimethyl-pyridin-2-ylmethyl)-9H-purin-2-ylamine

HRID 722111Notes

Reaction equation

HRID 722111 reaction equation
Br[CH2:2][C:3]1[C:8]([CH3:9])=[C:7]([CH3:10])[C:6]([CH3:11])=[CH:5][N:4]=1.[Cl:12][C:13]1[N:21]=[C:20]([NH2:22])[N:19]=[C:18]2[C:14]=1[N:15]=[CH:16][NH:17]2.C([O-])([O-])=O.[K+].[K+]>>[Cl:12][C:13]1[N:21]=[C:20]([NH2:22])[N:19]=[C:18]2[C:14]=1[N:15]=[CH:16][N:17]2[CH2:2][C:3]1[C:8]([CH3:9])=[C:7]([CH3:10])[C:6]([CH3:11])=[CH:5][N:4]=1

Participants

4

Reactant 3

HCID 11430Potassium CarbonateHCID 167350512-Bromomethyl-3,4,5-trimethyl-pyridineHCID 1785084356-chloro-1H-purin-2-amine

Product 1

HCID 167367676-Chloro-9-(3,4,5-trimethyl-pyridin-2-ylmethyl)-9H-purin-2-ylamine

Procedure

The compound was obtained by reacting 2-bromomethyl-3,4,5-trimethyl-pyridine with 6-chloro-9H-purin-2-ylamine in the presence of K2CO3 at 5° C. for 0.5 h as described in the general procedure 1.1. HPLC Rt: 3.903 min. 1H-NMR (CDCl3): δ 8.18 (s, 1H), 7.84 (s, 1H), 5.38 (s, 2H), 5.08 (s, 2H), 2.29 (s, 3H), 2.27 (s, 3H), 2.22 (s, 3H).

Workup

  1. customThe compound was obtained
  2. customat 5° C.
  3. customfor 0.5 h

Sources & evidence

ORD record
ord-e345e7145483418ba5d3dfa96b8eab7f
Source dataset
uspto-grants-2006_11
Patent number
US07138401B2

Reaction notes

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