Hydroxyamine hydrochloride → HCID 86591374, compound

HRID 722137Notes

Reaction equation

HRID 722137 reaction equation
[Br-].[F:2][C:3]1[C:4]2[CH2:5][CH:6]3[C:15](=[N+:16]4CCCC4)[CH:9]([CH2:10][C:11]=2[CH:12]=[CH:13][CH:14]=1)[CH2:8][CH2:7]3.Cl.NO.O.O.O.C([O-])(=[O:29])C.[Na+].C(O)C.O>O>[F:2][C:3]1[C:4]2[CH2:5][CH:6]3[C:15](=[N:16][OH:29])[CH:9]([CH2:10][C:11]=2[CH:12]=[CH:13][CH:14]=1)[CH2:8][CH2:7]3

Participants

6

Reactant 4

HCID 443297Hydroxyamine hydrochlorideHCID 19096565Water ethanolHCID 21882826HCID 21882826, compoundHCID 23665404Sodium Acetate Trihydrate

Product 1

HCID 86591374HCID 86591374, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

The product from Step 2 (1.02 g, 3.02 mmol), hydroxylamine hydrochloride (624 mg, 9.05 mmol) and sodium acetate trihydrate (1.23 g, 9.05 mmol) in 2:1 ethanol-water (12 ml) were heated to reflux and allowed to cool to room temperature, then stirred for 18 hours at this temperature. Water (10 ml) was added and the mixture filtered. The white solid was washed with water and dried under vacuum. 590 mg (89%). m/z 220 (M+H+).

Workup

  1. temperatureto reflux
  2. filtrationthe mixture filtered
  3. washThe white solid was washed with water
  4. customdried under vacuum

Sources & evidence

ORD record
ord-1b8657041d6a4dd0be665e472c1fa7d6
Source dataset
uspto-grants-2006_11
Patent number
US07138400B2

Reaction notes

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