Dimethylformamide dimethyl acetal → 5-Cyclopentanecarbonyl-3-(dimethylaminomethyleneamino)thiophene-2-carboxylic acid methyl ester

HRID 72215Notes

Reaction equation

HRID 72215 reaction equation
[CH3:1][O:2][C:3]([C:5]1[S:6][C:7]([C:11]([CH:13]2[CH2:17][CH2:16][CH2:15][CH2:14]2)=[O:12])=[CH:8][C:9]=1[NH2:10])=[O:4].CO[CH:20]([N:23]([CH3:25])[CH3:24])OC>>[CH3:1][O:2][C:3]([C:5]1[S:6][C:7]([C:11]([CH:13]2[CH2:17][CH2:16][CH2:15][CH2:14]2)=[O:12])=[CH:8][C:9]=1[N:10]=[CH:20][N:23]([CH3:25])[CH3:24])=[O:4]

Participants

3

Reactant 2

HCID 78373Dimethylformamide dimethyl acetalHCID 689435563-Amino-5-cyclopentanecarbonylthiophene-2-carboxylic acid methyl ester

Product 1

HCID 689456785-Cyclopentanecarbonyl-3-(dimethylaminomethyleneamino)thiophene-2-carboxylic acid methyl ester

Procedure

3-Amino-5-cyclopentanecarbonylthiophene-2-carboxylic acid methyl ester and dimethoxymethyldimethylamine were reacted by method B. The product with the molecular weight of 308.40 (C15H20N2O3S) was obtained in this way; MS (ESI): 309 (14+H+).

Workup

  1. customThe product with the molecular weight of 308.40 (C15H20N2O3S) was obtained in this way

Sources & evidence

ORD record
ord-2dffbdedeb2d426e859d6edf818161c8
Source dataset
uspto-grants-2014_09
Patent number
US08828991B2

Reaction notes

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