Benzoyl isocyanate, 2-chloro-4-fluoro- → HCID 178488181, compound

HRID 722205Notes

Reaction equation

HRID 722205 reaction equation
[Cl:1][C:2]1[CH:12]=[C:11]([F:13])[CH:10]=[CH:9][C:3]=1[C:4]([N:6]=[C:7]=[O:8])=[O:5].[CH3:14][O:15][C:16]1[CH:17]=[C:18]([C:25]2[NH:26][C:27]([CH2:30][C:31]([O-:33])=[O:32])=[N:28][N:29]=2)[CH:19]=[CH:20][C:21]=1[N+:22]([O-])=O>C(#N)C>[Cl:1][C:2]1[CH:12]=[C:11]([F:13])[CH:10]=[CH:9][C:3]=1[C:4]([NH:6][C:7](=[O:8])[NH:22][C:21]1[CH:20]=[CH:19][C:18]([C:25]2[NH:26][C:27]([CH2:30][C:31]([OH:33])=[O:32])=[N:28][N:29]=2)=[CH:17][C:16]=1[O:15][CH3:14])=[O:5]

Participants

4

Reactant 2

HCID 11521269Benzoyl isocyanate, 2-chloro-4-fluoro-HCID 178488182HCID 178488182, compound

Product 1

HCID 178488181HCID 178488181, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent2×

Procedure

The solution of equivalent amounts of 2-chloro-4-fluorobenzoyl isocyanate in acetonitrile was added dropwise to the solution of 89 mg of [5-(3-methoxy-4-nitrophenyl)-4H-[1,2,4]triazol-3-yl]acetate in 5 ml of acetonitrile and the mixture was stirred at room temperature overnight. The solid formed was then filtered off with suction and dried under reduced pressure.

Workup

  1. customThe solid formed
  2. filtrationwas then filtered off with suction
  3. customdried under reduced pressure

Sources & evidence

ORD record
ord-dae1b33701a9447e952ac0bccac2edd9
Source dataset
uspto-grants-2006_11
Patent number
US07138414B2

Reaction notes

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