2-Chloro-4,5-difluorobenzoyl Isocyanate → HCID 178433949, compound

HRID 722210Notes

Reaction equation

HRID 722210 reaction equation
[Cl:1][C:2]1[CH:12]=[C:11]([F:13])[C:10]([F:14])=[CH:9][C:3]=1[C:4]([N:6]=[C:7]=[O:8])=[O:5].[NH2:15][C:16]1[CH:17]=[C:18]([C:23]2[NH:27][C:26]([CH3:28])=[N:25][N:24]=2)[CH:19]=[CH:20][C:21]=1[Cl:22]>C(#N)C>[Cl:1][C:2]1[CH:12]=[C:11]([F:13])[C:10]([F:14])=[CH:9][C:3]=1[C:4]([NH:6][C:7]([NH:15][C:16]1[CH:17]=[C:18]([C:23]2[NH:27][C:26]([CH3:28])=[N:25][N:24]=2)[CH:19]=[CH:20][C:21]=1[Cl:22])=[O:8])=[O:5]

Participants

4

Reactant 2

HCID 115575832-Chloro-4,5-difluorobenzoyl IsocyanateHCID 178433948HCID 178433948, compound

Product 1

HCID 178433949HCID 178433949, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

The solution of equivalent amounts of 2-chloro-4,5-difluorobenzoyl isocyanate was added dropwise to the solution of 85 mg of 3-(3-amino-4-chlorophenyl)-5-methyl-4H-1,2,4-triazole in 8 ml of acetonitrile and the mixture was stirred at room temperature for 2 hours. The solid formed is then filtered off with suction and dried under reduced pressure.

Workup

  1. customThe solid formed
  2. filtrationis then filtered off with suction
  3. customdried under reduced pressure

Sources & evidence

ORD record
ord-5d1a2a01d5114bea9f91e89a8ae4a86c
Source dataset
uspto-grants-2006_11
Patent number
US07138414B2

Reaction notes

Loading…