Hydroxyamine hydrochloride → N-[4-[(E)-N'-hydroxycarbamimidoyl]-2-(trifluoromethoxy)phenyl]acetamide

Participants

Reaction Steps

The mixture consisting of 610 mg of N-(4-cyano-2-trifluoromethoxyphenyl)-acetamide, 15 ml of isopropanol, 255 mg of hydroxylamine hydrochloride and 410 mg of sodium acetate was heated to reflux for 5 hours. After cooling, the insoluble fraction was filtered off, and the filtrate is concentrated and taken up in a little isopropanol, the product was precipitated, filtered off with suction and dried by adding water until the first cloudiness and subsequent stirring.

Provenance & Evidence