反应详情

The mixture consisting of 610 mg of N-(4-cyano-2-trifluoromethoxyphenyl)-acetamide, 15 ml of isopropanol, 255 mg of hydroxylamine hydrochloride and 410 mg of sodium acetate was heated to reflux for 5 hours. After cooling, the insoluble fraction was filtered off, and the filtrate is concentrated and taken up in a little isopropanol, the product was precipitated, filtered off with suction and dried by adding water until the first cloudiness and subsequent stirring.

1. temperaturewas heated
2. temperatureto reflux for 5 hours
3. temperatureAfter cooling
4. filtrationthe insoluble fraction was filtered off
5. concentrationthe filtrate is concentrated
6. customthe product was precipitated
7. filtrationfiltered off with suction
8. customdried
9. additionby adding water until the first cloudiness and subsequent stirring