HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 3-(4-amino-3-trifluoromethoxyphenyl)-4H-[1,2,4]-oxadiazol-5-one hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Methanol | HCID 887 | — |
| Reactant | N-[4-(5-oxo-4,5-dihydro-[1,2,4]oxadiazol-3-yl)-2-trifluoromethoxyphenyl]acetamide | HCID 135839374 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 3-(4-amino-3-trifluoromethoxyphenyl)-4H-[1,2,4]-oxadiazol-5-one hydrochloride | HCID 136360624 | — |
Reaction Steps
The mixture consisting of 200 mg of N-[4-(5-oxo-4,5-dihydro-[1,2,4]oxadiazol-3-yl)-2-trifluoromethoxyphenyl]acetamide, 10 ml of methanol and 0.5 ml of a 4M solution of hydrochloric acid in dioxane was stirred at room temperature for 15 hours. After concentrating the volatile fractions on a rotary evaporator, a yellowish oil remains.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07138414B2 |
| Source dataset | uspto-grants-2006_11 |
| ORD ID | ord-7669183fc8fa4123a4e51df9ac4b45c4 |
| Source note | uspto-grants-2006_11 |