2-(1H-Benzimidazol-2-yl)aniline → HCID 21883861, compound

HRID 722227Notes

Reaction equation

HRID 722227 reaction equation
[Cl:1][C:2]1[CH:12]=[C:11]([F:13])[C:10]([F:14])=[CH:9][C:3]=1[C:4]([N:6]=[C:7]=[O:8])=[O:5].[NH:15]1[C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][C:18]=2[N:17]=[C:16]1[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=1[NH2:30]>C(#N)C>[NH:15]1[C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][C:18]=2[N:17]=[C:16]1[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=1[NH:30][C:7]([NH:6][C:4](=[O:5])[C:3]1[CH:9]=[C:10]([F:14])[C:11]([F:13])=[CH:12][C:2]=1[Cl:1])=[O:8]

Participants

4

Reactant 2

HCID 798692-(1H-Benzimidazol-2-yl)anilineHCID 115575832-Chloro-4,5-difluorobenzoyl Isocyanate

Product 1

HCID 21883861HCID 21883861, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

The solution of equivalent amounts of 2-chloro-4,5-difluorobenzoyl isocyanate was added dropwise to the solution of 142 mg of 2-(1H-benzimidazol-2-yl)phenylamine in 8 ml of acetonitrile and the mixture was stirred at room temperature for 30 minutes. The solid was then filtered off with suction and dried under reduced pressure.

Workup

  1. filtrationThe solid was then filtered off with suction
  2. customdried under reduced pressure

Sources & evidence

ORD record
ord-e08d567c9c1549fa86ac375ec65cca48
Source dataset
uspto-grants-2006_11
Patent number
US07138414B2

Reaction notes

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