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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 72223Generated: October 30, 2026

Dimethylformamide dimethyl acetal → 3-(Dimethylaminomethyleneamino)-5-(4-hydroxytetrahydropyran-4-yl)thiophene-2-carboxylic acid methyl ester

https://huagongshe.com/reaction/72223

Reaction equation

Participants

RoleNameHCIDCharge
ReactantDimethylformamide dimethyl acetalHCID 78373—
ReactantHCID 68941697HCID 68941697—
Product3-(Dimethylaminomethyleneamino)-5-(4-hydroxytetrahydropyran-4-yl)thiophene-2-carboxylic acid methyl esterHCID 68940274—

Reaction Steps

3-Amino-5-(4-hydroxytetrahydropyran-4-yl)thiophene-2-carboxylic acid methyl ester and dimethoxymethyldimethylamine were reacted by method B. The product with the molecular weight of 312.39 (C14H20N2O4S) was obtained in this way; MS (ESI): 313 (+H+).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08828991B2
Source datasetuspto-grants-2014_09
ORD IDord-1ff2fe99b0464d9f80b019ecd949478b
Source noteuspto-grants-2014_09