Dimethylformamide dimethyl acetal → 3-(Dimethylaminomethyleneamino)-5-(4-hydroxytetrahydropyran-4-yl)thiophene-2-carboxylic acid methyl ester

HRID 72223Notes

Reaction equation

HRID 72223 reaction equation
[CH3:1][O:2][C:3]([C:5]1[S:6][C:7]([C:11]2([OH:17])[CH2:16][CH2:15][O:14][CH2:13][CH2:12]2)=[CH:8][C:9]=1[NH2:10])=[O:4].CO[CH:20]([N:23]([CH3:25])[CH3:24])OC>>[CH3:1][O:2][C:3]([C:5]1[S:6][C:7]([C:11]2([OH:17])[CH2:12][CH2:13][O:14][CH2:15][CH2:16]2)=[CH:8][C:9]=1[N:10]=[CH:20][N:23]([CH3:25])[CH3:24])=[O:4]

Participants

3

Reactant 2

HCID 78373Dimethylformamide dimethyl acetalHCID 68941697HCID 68941697, compound

Product 1

HCID 689402743-(Dimethylaminomethyleneamino)-5-(4-hydroxytetrahydropyran-4-yl)thiophene-2-carboxylic acid methyl ester

Procedure

3-Amino-5-(4-hydroxytetrahydropyran-4-yl)thiophene-2-carboxylic acid methyl ester and dimethoxymethyldimethylamine were reacted by method B. The product with the molecular weight of 312.39 (C14H20N2O4S) was obtained in this way; MS (ESI): 313 (+H+).

Workup

  1. customThe product with the molecular weight of 312.39 (C14H20N2O4S) was obtained in this way

Sources & evidence

ORD record
ord-1ff2fe99b0464d9f80b019ecd949478b
Source dataset
uspto-grants-2014_09
Patent number
US08828991B2

Reaction notes

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