2-Chloro-4,5-difluorobenzoyl Isocyanate → HCID 135839375, compound

HRID 722230Notes

Reaction equation

HRID 722230 reaction equation
[Cl:1][C:2]1[CH:12]=[C:11]([F:13])[C:10]([F:14])=[CH:9][C:3]=1[C:4]([N:6]=[C:7]=[O:8])=[O:5].[NH2:15][C:16]1[CH:17]=[C:18]([C:23]2[NH:28][C:27](=[O:29])[C:26]([CH3:30])=[N:25][N:24]=2)[CH:19]=[CH:20][C:21]=1[Cl:22]>C(#N)C>[Cl:1][C:2]1[CH:12]=[C:11]([F:13])[C:10]([F:14])=[CH:9][C:3]=1[C:4]([NH:6][C:7]([NH:15][C:16]1[CH:17]=[C:18]([C:23]2[NH:28][C:27](=[O:29])[C:26]([CH3:30])=[N:25][N:24]=2)[CH:19]=[CH:20][C:21]=1[Cl:22])=[O:8])=[O:5]

Participants

4

Reactant 2

HCID 115575832-Chloro-4,5-difluorobenzoyl IsocyanateHCID 1358393793-(3-Amino-4-chlorophenyl)-6-methyl-1,2,4-triazin-5(2H)-one

Product 1

HCID 135839375HCID 135839375, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

The solution of equivalent amounts of 2-chloro-4,5-difluorobenzoyl isocyanate was added dropwise to the solution of 60 mg of 3-(3-amino-4-chlorophenyl)-6-methyl-4H-[1,2,4]triazin-5-one in 8 ml of acetonitrile and the mixture was stirred at room temperature for 30 minutes. The solid was filtered off with suction and dried under reduced pressure.

Workup

  1. filtrationThe solid was filtered off with suction
  2. customdried under reduced pressure

Sources & evidence

ORD record
ord-c2e24785cb60435685d75a79acee1987
Source dataset
uspto-grants-2006_11
Patent number
US07138414B2

Reaction notes

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