HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 722232Generated: October 29, 2026
N-methyl-2-pyrrolidone → 1-(4-Fluoro-2-nitrophenyl)piperidine-3-carboxamide
https://huagongshe.com/reaction/722232
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Reactant | 2,5-Difluoronitrobenzene | HCID 67767 | — |
| Reactant | 3-Piperidinecarboxamide | HCID 92980 | — |
| Solvent | Water | HCID 962 | — |
| Product | 1-(4-Fluoro-2-nitrophenyl)piperidine-3-carboxamide | HCID 21883912 | — |
Reaction Steps
The mixture consisting of 1.62 g of 2,5-difluoronitrobenzene, 1.9 g of nipecotamide and 10 ml of NMP was heated with stirring to 80° C. for 2 hours. After the mixture had been allowed to cool, 30 ml of water were added and the mixture was stirred at RT for 30 minutes. The precipitated solid was filtered off with suction and dried under reduced pressure.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07138414B2 |
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| Source dataset | uspto-grants-2006_11 |
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| ORD ID | ord-74461f99bffd49d08ace61153edfed1a |
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| Source note | uspto-grants-2006_11 |
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