Water → HCID 69439418, compound

HRID 722238Notes

Reaction equation

HRID 722238 reaction equation
[Cl:1][C:2]1[CH:29]=[C:28]([F:30])[C:27]([F:31])=[CH:26][C:3]=1[C:4]([NH:6][C:7](=[O:25])[NH:8][C:9]1[CH:14]=[C:13]([F:15])[CH:12]=[CH:11][C:10]=1[N:16]1[CH2:21][CH2:20][CH:19]([C:22]([OH:24])=[O:23])[CH2:18][CH2:17]1)=[O:5].[OH-].[Na+:33].O>C(O)(C)C>[Na+:33].[Cl:1][C:2]1[CH:29]=[C:28]([F:30])[C:27]([F:31])=[CH:26][C:3]=1[C:4]([NH:6][C:7](=[O:25])[NH:8][C:9]1[CH:14]=[C:13]([F:15])[CH:12]=[CH:11][C:10]=1[N:16]1[CH2:17][CH2:18][CH:19]([C:22]([O-:24])=[O:23])[CH2:20][CH2:21]1)=[O:5]

Participants

5

Reactant 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 12148754AVE2865

Product 1

HCID 69439418HCID 69439418, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

The solution of 100 mg of 1-{2-[3-(2-chloro-4,5-difluorobenzoyl)ureido]-4-fluoro-phenyl}piperidine-4-carboxylic acid in 8 ml of isopropanol at 60° C. is admixed with the equimolar amount of 2N sodium hydroxide solution and, after the addition of 20 ml of water, cooled slowly with stirring. The precipitated product is filtered off with suction, washed with isopropanol and water and dried under reduced pressure.

Workup

  1. customat 60° C.
  2. temperaturecooled slowly
  3. filtrationThe precipitated product is filtered off with suction
  4. washwashed with isopropanol and water
  5. customdried under reduced pressure

Sources & evidence

ORD record
ord-3b5c905885d243f981e23f7008678800
Source dataset
uspto-grants-2006_11
Patent number
US07138414B2

Reaction notes

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