Trifluoroacetic acid → HCID 24886523, compound

HRID 722266Notes

Reaction equation

HRID 722266 reaction equation
C(O)(C(F)(F)F)=O.[C:8]([N:11]([CH2:34][C:35]([O:37]C(C)(C)C)=[O:36])[C@@H:12]1[C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[CH2:14][C@H:13]1[NH:21][C:22]([C:24]1[NH:25][C:26]2[C:31]([CH:32]=1)=[CH:30][C:29]([Cl:33])=[CH:28][CH:27]=2)=[O:23])(=[O:10])[CH3:9]>C(Cl)Cl>[C:8]([N:11]([C@@H:12]1[C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[CH2:14][C@H:13]1[NH:21][C:22]([C:24]1[NH:25][C:26]2[C:31]([CH:32]=1)=[CH:30][C:29]([Cl:33])=[CH:28][CH:27]=2)=[O:23])[CH2:34][C:35]([OH:37])=[O:36])(=[O:10])[CH3:9]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 58742487HCID 58742487, compound

Product 1

HCID 24886523HCID 24886523, compoundYield 83%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

TFA (5 mL) was added to a solution of 1,1-dimethylethyl [acetyl((1R,2R)-2-{[(5-chloro-1H-indol-2-yl)carbonyl]amino}-2,3-dihydro-1H-inden-1-yl)amino]acetate (Method 9, 138 mg, 0.3 mmol) in DCM (10 mL) and the reaction was stirred at ambient temperature for 1 h. The volatiles were removed by evaporation under reduced pressure to afford the title compound (100 mg, 83%) as a white solid.

Workup

  1. customThe volatiles were removed by evaporation under reduced pressure

Sources & evidence

ORD record
ord-90fca3cf76e54eb79d91068d755d340c
Source dataset
uspto-grants-2006_11
Patent number
US07138415B2

Reaction notes

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