Sodium borohydride → 6-[Hydroxy(tetrahydropyran-4-yl)methyl]-3-[4-(4-methyl[1,4]diazepan-1-yl)phenyl]-3H-thieno[3,2-d]pyrimidin-4-one

HRID 72227Notes

Reaction equation

HRID 72227 reaction equation
[CH3:1][N:2]1[CH2:8][CH2:7][CH2:6][N:5]([C:9]2[CH:14]=[CH:13][C:12]([N:15]3[C:20](=[O:21])[C:19]4[S:22][C:23]([C:25]([CH:27]5[CH2:32][CH2:31][O:30][CH2:29][CH2:28]5)=[O:26])=[CH:24][C:18]=4[N:17]=[CH:16]3)=[CH:11][CH:10]=2)[CH2:4][CH2:3]1.[BH4-].[Na+]>>[OH:26][CH:25]([CH:27]1[CH2:32][CH2:31][O:30][CH2:29][CH2:28]1)[C:23]1[S:22][C:19]2[C:20](=[O:21])[N:15]([C:12]3[CH:11]=[CH:10][C:9]([N:5]4[CH2:6][CH2:7][CH2:8][N:2]([CH3:1])[CH2:3][CH2:4]4)=[CH:14][CH:13]=3)[CH:16]=[N:17][C:18]=2[CH:24]=1

Participants

3

Reactant 2

HCID 4311764Sodium borohydrideHCID 24859572HCID 24859572, compound

Product 1

HCID 248597076-[Hydroxy(tetrahydropyran-4-yl)methyl]-3-[4-(4-methyl[1,4]diazepan-1-yl)phenyl]-3H-thieno[3,2-d]pyrimidin-4-one

Procedure

3-[4-(4-Methyl[1,4]diazepan-1-yl)phenyl]-6-(tetrahydropyran-4-carbonyl)-3H-thieno[3,2-d]pyrimidin-4-one and sodium borohydride were reacted by method Y. The product with the molecular weight of 454.60 (C24H30N4O3S) was obtained in this way; MS (ESI): 455 (M+H+).

Workup

  1. customThe product with the molecular weight of 454.60 (C24H30N4O3S) was obtained in this way

Sources & evidence

ORD record
ord-05bf72ce54b042e0a9244af8981919c9
Source dataset
uspto-grants-2014_09
Patent number
US08828991B2

Reaction notes

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