p-Toluenesulfonic acid → 3-[4-(4-Methyl[1,4]diazepan-1-yl)phenyl]-6-(2-methyl-4,5-dihydrofuran-3-yl)-3H-thieno[3,2-d]pyrimidin-4-one

HRID 72234Notes

Reaction equation

HRID 72234 reaction equation
O[C:2]1([C:8]2[S:16][C:15]3[C:14](=[O:17])[N:13]([C:18]4[CH:23]=[CH:22][C:21]([N:24]5[CH2:30][CH2:29][CH2:28][N:27]([CH3:31])[CH2:26][CH2:25]5)=[CH:20][CH:19]=4)[CH:12]=[N:11][C:10]=3[CH:9]=2)[CH2:6][CH2:5][O:4][CH:3]1[CH3:7].C1(C)C=CC(S(O)(=O)=O)=CC=1>>[CH3:31][N:27]1[CH2:28][CH2:29][CH2:30][N:24]([C:21]2[CH:22]=[CH:23][C:18]([N:13]3[C:14](=[O:17])[C:15]4[S:16][C:8]([C:2]5[CH2:6][CH2:5][O:4][C:3]=5[CH3:7])=[CH:9][C:10]=4[N:11]=[CH:12]3)=[CH:19][CH:20]=2)[CH2:25][CH2:26]1

Participants

3

Reactant 2

HCID 6101p-Toluenesulfonic acidHCID 248597056-(3-Hydroxy-2-methyltetrahydrofuran-3-yl)-3-[4-(4-methyl[1,4]diazepan-1-yl)phenyl]-3H-thieno[3,2-d]pyrimidin-4-one

Product 1

HCID 248598443-[4-(4-Methyl[1,4]diazepan-1-yl)phenyl]-6-(2-methyl-4,5-dihydrofuran-3-yl)-3H-thieno[3,2-d]pyrimidin-4-one

Procedure

6-(3-Hydroxy-2-methyltetrahydrofuran-3-yl)-3-[4-(4-methyl[1,4]diazepan-1-yl)phenyl]-3H-thieno[3,2-d]pyrimidin-4-one and p-toluenesulfonic acid were reacted by method AA. The product with the molecular weight of 422.55 (C23H26N4O2S) was obtained in this way; MS (ESI): 423 (M+H+).

Workup

  1. customThe product with the molecular weight of 422.55 (C23H26N4O2S) was obtained in this way

Sources & evidence

ORD record
ord-e073a26b0062417d88ea7795d8c1b2b3
Source dataset
uspto-grants-2014_09
Patent number
US08828991B2

Reaction notes

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