Salicylaldehyde → 5-Chloro-4-fluoro-2-hydroxybenzaldehyde

HRID 722362Notes

Reaction equation

HRID 722362 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][C:3]=1[F:9].C(=O)C1[C:12](=CC=CC=1)[OH:13]>>[Cl:1][C:2]1[CH:7]=[C:6]([CH:12]=[O:13])[C:5]([OH:8])=[CH:4][C:3]=1[F:9]

Participants

3

Reactant 2

HCID 6998SalicylaldehydeHCID 27245234-Chloro-3-fluorophenol2×

Product 1

HCID 71721325-Chloro-4-fluoro-2-hydroxybenzaldehyde

Procedure

4-Chloro-3-fluorophenol (Avocado product #16029) was converted to the salicylaldehyde via a method similar to that described in Example 2, Step 1: mp 102.7–103.7° C. 1H NMR (CDCl3/300 MHz) 11.22 (d, 1H, J=1.6 Hz), 9.80 (s, 1H), 7.63 (d, 1H, J=7.9 Hz), 6.77 (d, 1H, J=10.3 Hz). 19F NMR (CDCl3/282 MHz) −100.3 (t).

Sources & evidence

ORD record
ord-6f62b5e537614914bbaea54a82615372
Source dataset
uspto-grants-2006_11
Patent number
US07138411B2

Reaction notes

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