反应详情

温度

80 °C

A stirred mixture of 102 mg (0.14 mmol) of compound 10a, generated in Example 10, Step A, 30.6 mg (0.29 mmol) of palladium black and 181.2 mg (0.29 mmol) ammonium formate in 3 mL of EtOH/EtOAc/H2O (7:2:1) was heated at 80° C. for 2 h. The reaction mixture was filtered through a pad of Celite® to remove the catalyst, washed thoroughly with EtOH/EtOAc/H2O (7:2:1), and the filtrate was partitioned between water and EtOAc. The organic phase was separated, dried over Na2SO4, filtered, evaporated, and dried in vacuo to give the crude product which was used without purification.

1. filtrationThe reaction mixture was filtered through a pad of Celite®
2. customto remove the catalyst
3. washwashed thoroughly with EtOH/EtOAc/H2O (7:2:1)
4. customthe filtrate was partitioned between water and EtOAc
5. customThe organic phase was separated
6. dry with materialdried over Na2SO4
7. filtrationfiltered
8. customevaporated
9. customdried in vacuo