反应详情

A mixture of 6-(tert-Butyl-diphenyl-silanyloxymethyl)-3-[4-(3-dimethylamino-pyrrolidin-1-yl)-phenyl]-3H-thieno[3,2-d]pyrimidin-4-one (1.4 g) and 1 M solution of Tetra-N-butylammoniumfluoride in THF (2.7 mL) in THF (20.0 mL) was stirred at room temperature for 3 h. The solvent was removed in vacuo and the crude product was purified by preparative HPLC. The product with the molecular weight of 370.47 (C19H22N4O2S) was obtained in this way; MS (ESI): 371 (M+H+).

1. customThe solvent was removed in vacuo
2. customthe crude product was purified by preparative HPLC
3. customThe product with the molecular weight of 370.47 (C19H22N4O2S) was obtained in this way