反应详情

To a suspension of 3-tert-butoxycarbonylamino-5-formyl-thiophene-2-carboxylic acid methyl ester (1.49 g) in ethanol/water (95 mL/95 mL) sodiumborohydride (105.8 mg) was added at 0° C. The mixture was stirred for 1 h at this temperature. Then ethyl acetate and water were added. The aqueous phase was extracted several times with ethyl acetate, the combined organic phases dried over sodium sulfate and the solvent removed in vacuo. The product with the molecular weight of 287.33 (C12H17NO5S) was obtained in this way; MS (ESI): 288 (M+H+).

1. additionwas added at 0° C
2. extractionThe aqueous phase was extracted several times with ethyl acetate
3. dry with materialthe combined organic phases dried over sodium sulfate
4. customthe solvent removed in vacuo
5. customThe product with the molecular weight of 287.33 (C12H17NO5S) was obtained in this way