Iodoacetamide → HCID 58742321, compound

HRID 722436Notes

Reaction equation

[CH2:1]([C@:3]12[C:16]3[C:11](=[CH:12][C:13]([OH:17])=[CH:14][CH:15]=3)[CH2:10][CH2:9][C@@H:8]1[CH2:7][C@:6]([C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][N:20]=1)([OH:18])[C@:5]([CH3:26])([OH:25])[CH2:4]2)[CH3:2].I[CH2:28][C:29]([NH2:31])=[O:30]>>[CH2:1]([C@@:3]12[CH2:4][C@:5]([OH:25])([CH3:26])[C@:6]([OH:18])([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][N:20]=3)[CH2:7][C@H:8]1[CH2:9][CH2:10][C:11]1[CH:12]=[C:13]([O:17][CH2:28][C:29]([NH2:31])=[O:30])[CH:14]=[CH:15][C:16]2=1)[CH3:2]

Participants

Reactant 2

HCID 3727Iodoacetamide

HCID 10450738HCID 10450738, compound

Product 1

HCID 58742321HCID 58742321, compound

Procedure

The title compound was prepared from the compound of Example 102 according to the procedure of Example 57, running the reaction at room temperature overnight and using iodoacetamide as the alkylating agent. Mass spectrum (m/e) 411 (M++1).

Workup

customthe reaction at room temperature overnight

Sources & evidence

ORD record: ord-a2117948a9fc4505b8b23a7d515cbf76
Source dataset: uspto-grants-2006_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07138406B2

Reaction notes

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