2,4-Difluorophenylboronic acid → HCID 21884579, compound

HRID 722513Notes

Reaction equation

HRID 722513 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]([C:12]2[O:13][C:14]3[CH:20]=[CH:19][C:18](Br)=[CH:17][C:15]=3[N:16]=2)[CH:7]=[CH:8][C:9]=1[O:10][CH3:11])([O-:3])=[O:2].[F:22][C:23]1[CH:28]=[C:27]([F:29])[CH:26]=[CH:25][C:24]=1B(O)O>>[N+:1]([C:4]1[CH:5]=[C:6]([C:12]2[O:13][C:14]3[CH:20]=[CH:19][C:18]([C:26]4[CH:25]=[CH:24][C:23]([F:22])=[CH:28][C:27]=4[F:29])=[CH:17][C:15]=3[N:16]=2)[CH:7]=[CH:8][C:9]=1[O:10][CH3:11])([O-:3])=[O:2]

Participants

3

Reactant 2

HCID 27343342,4-Difluorophenylboronic acidHCID 218843422-(3-Nitro-4-methoxyphenyl)-5-bromobenzoxazole

Product 1

HCID 21884579HCID 21884579, compound

Procedure

Prepared by the method of Example 15d), from 2-(3-nitro-4-methoxyphenyl)-5-bromobenzoxazole (200 mg, 0.57 mmol) and 2,4-difluorophenylboronic acid (136 mg, 0.86 mmol) the subtitle compound was obtained, (57 mg, 26%). 1H NMR (DMSO) δ 8.71(d, 1H), 8.53(dd, 1H), 8.01(s, 1H), 7.97(d, 1H), 7.70(m, 3H), 7.48(dt, 1H), 7.30(dt, 1H), 4.12(s, 3H). MS 383 m/z (M+H)+.

Sources & evidence

ORD record
ord-a89226e51c2f4ab883bca512094f593a
Source dataset
uspto-grants-2006_11
Patent number
US07138425B2

Reaction notes

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