2-(3-Nitro-6-methoxyphenyl)-5-phenylbenzoxazole → 2-(3-Amino-6-methoxyphenyl)-5-phenylbenzoxazole

HRID 722521Notes

Reaction equation

HRID 722521 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]([C:12]2[O:13][C:14]3[CH:20]=[CH:19][C:18]([C:21]4[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=4)=[CH:17][C:15]=3[N:16]=2)[C:7]([O:10][CH3:11])=[CH:8][CH:9]=1)([O-])=O>[Pd]>[NH2:1][C:4]1[CH:5]=[C:6]([C:12]2[O:13][C:14]3[CH:20]=[CH:19][C:18]([C:21]4[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=4)=[CH:17][C:15]=3[N:16]=2)[C:7]([O:10][CH3:11])=[CH:8][CH:9]=1

Participants

3

Reactant 1

HCID 218843862-(3-Nitro-6-methoxyphenyl)-5-phenylbenzoxazole

Product 1

HCID 218844572-(3-Amino-6-methoxyphenyl)-5-phenylbenzoxazole

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

Prepared by the method of Example 15e), from palladium (10 mol %) on carbon and 2-(3-nitro-6-methoxyphenyl)-5-phenylbenzoxazole (450 mg, 1.3 mmol) the subtitle compound was obtained (420 mg, 99%). The product was used directly in the next step without purification.

Sources & evidence

ORD record
ord-f9788927e70c458b94df1968c9ca1976
Source dataset
uspto-grants-2006_11
Patent number
US07138425B2

Reaction notes

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