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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 722529Generated: October 30, 2026

2-(2-Fluoro-5-nitrophenyl)-5-phenylbenzoxazole → 2-(5-Nitro-2-isopropoxyphenyl)-5-phenylbenzoxazole

https://huagongshe.com/reaction/722529

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-(2-Fluoro-5-nitrophenyl)-5-phenylbenzoxazoleHCID 21884334—
SolventIsopropanolHCID 3776—
Product2-(5-Nitro-2-isopropoxyphenyl)-5-phenylbenzoxazoleHCID 21884584—

Reaction Steps

Prepared by the method of Example 44a), from 2-(2-fluoro-5-nitrophenyl)-5-phenylbenzoxazole (200 mg, 0.6 mmol) and isopropanol (2 ml) the subtitle compound was obtained (204 mg, 84%). 1H NMR (DMSO) δ 8.85(d, 1H), 8.44(dd, 1H), 8.12(d, 1H), 7.90(d, 1H), 7.76(m, 3H), 7.54(m, 3H), 7.40(t, 1H), 4.35(m, 1H), 1.45(d, 6H).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07138425B2
Source datasetuspto-grants-2006_11
ORD IDord-bda7f9244f8940bb82f9e4130ea95638
Source noteuspto-grants-2006_11