2-(2-Fluoro-5-nitrophenyl)-5-phenylbenzoxazole → 2-(5-Nitro-2-isopropoxyphenyl)-5-phenylbenzoxazole

HRID 722529Notes

Reaction equation

HRID 722529 reaction equation
F[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][C:3]=1[C:11]1[O:12][C:13]2[CH:19]=[CH:18][C:17]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)=[CH:16][C:14]=2[N:15]=1>C(O)(C)C>[N+:8]([C:5]1[CH:6]=[CH:7][C:2]([O:12][CH:13]([CH3:19])[CH3:14])=[C:3]([C:11]2[O:12][C:13]3[CH:19]=[CH:18][C:17]([C:20]4[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=4)=[CH:16][C:14]=3[N:15]=2)[CH:4]=1)([O-:10])=[O:9]

Participants

3

Reactant 1

HCID 218843342-(2-Fluoro-5-nitrophenyl)-5-phenylbenzoxazole

Product 1

HCID 218845842-(5-Nitro-2-isopropoxyphenyl)-5-phenylbenzoxazole

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

Prepared by the method of Example 44a), from 2-(2-fluoro-5-nitrophenyl)-5-phenylbenzoxazole (200 mg, 0.6 mmol) and isopropanol (2 ml) the subtitle compound was obtained (204 mg, 84%). 1H NMR (DMSO) δ 8.85(d, 1H), 8.44(dd, 1H), 8.12(d, 1H), 7.90(d, 1H), 7.76(m, 3H), 7.54(m, 3H), 7.40(t, 1H), 4.35(m, 1H), 1.45(d, 6H).

Sources & evidence

ORD record
ord-bda7f9244f8940bb82f9e4130ea95638
Source dataset
uspto-grants-2006_11
Patent number
US07138425B2

Reaction notes

Loading…