Propylamine → HCID 21884648, compound

HRID 722564Notes

Reaction equation

[N+:1]([C:4]1[CH:5]=[C:6]([C:11]2[O:12][C:13]3[CH:19]=[C:18]([CH3:20])[CH:17]=[CH:16][C:14]=3[N:15]=2)[C:7](F)=[CH:8][CH:9]=1)([O-:3])=[O:2].[CH2:21]([NH2:24])[CH2:22][CH3:23]>>[N+:1]([C:4]1[CH:5]=[C:6]([C:11]2[O:12][C:13]3[CH:19]=[C:18]([CH3:20])[CH:17]=[CH:16][C:14]=3[N:15]=2)[C:7]([NH:24][CH2:21][CH2:22][CH3:23])=[CH:8][CH:9]=1)([O-:3])=[O:2]

Participants

Reactant 2

HCID 7852Propylamine

HCID 21884302HCID 21884302, compound

Product 1

HCID 21884648HCID 21884648, compound

Procedure

Prepared by the method of Example 54a), from 2-(3-nitro-6-fluorophenyl)-6-methylbenzoxazole (250 mg, 0.9 mmol) and propylamine (400 μL, 5.0 mmol) the subtitle compound was obtained (262 mg, 94%). 1H NMR (DMSO) δ 9.21(t, 1H), 8.78(d, 1H), 8.19(dd, 1H), 7.70–7.66(m, 2H), 7.25(d, 1H), 7.03(d, 1H), 3.43(q, 2H), 2.47(s, 3H), 1.73(m, 2H), 1.01(t, 3H).

Sources & evidence

ORD record: ord-976229f2d61542228db057f836802409
Source dataset: uspto-grants-2006_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07138425B2

Reaction notes

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