Propylamine → 2-(3-Nitro-6-propylaminophenyl)-5,7-dichlorobenzoxazole

HRID 722579Notes

Reaction equation

HRID 722579 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]([C:11]2[O:12][C:13]3[C:19]([Cl:20])=[CH:18][C:17]([Cl:21])=[CH:16][C:14]=3[N:15]=2)[C:7](F)=[CH:8][CH:9]=1)([O-:3])=[O:2].[CH2:22]([NH2:25])[CH2:23][CH3:24]>>[N+:1]([C:4]1[CH:5]=[C:6]([C:11]2[O:12][C:13]3[C:19]([Cl:20])=[CH:18][C:17]([Cl:21])=[CH:16][C:14]=3[N:15]=2)[C:7]([NH:25][CH2:22][CH2:23][CH3:24])=[CH:8][CH:9]=1)([O-:3])=[O:2]

Participants

3

Reactant 2

HCID 7852PropylamineHCID 218844902-(3-Nitro-6-fluorophenyl)-5,7-dichlorobenzoxazole

Product 1

HCID 218842932-(3-Nitro-6-propylaminophenyl)-5,7-dichlorobenzoxazole

Procedure

Prepared by the method of Example 54a), from 2-(3-nitro-6-fluorophenyl)-5,7-dichlorobenzoxazole (250 mg, 0.8 mmol) and propylamine (328 μL, 4.0 mmol) the subtitle compound was obtained. The product was used directly in the next step without purification.

Sources & evidence

ORD record
ord-b942c25b4b724d2a88d142e11292dc56
Source dataset
uspto-grants-2006_11
Patent number
US07138425B2

Reaction notes

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