Propylamine → 2-(3-Nitro-6-propylaminophenyl)-5-trifluoromethylbenzoxazole

HRID 722582Notes

Reaction equation

HRID 722582 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]([C:11]2[O:12][C:13]3[CH:19]=[CH:18][C:17]([C:20]([F:23])([F:22])[F:21])=[CH:16][C:14]=3[N:15]=2)[C:7](F)=[CH:8][CH:9]=1)([O-:3])=[O:2].[CH2:24]([NH2:27])[CH2:25][CH3:26]>>[N+:1]([C:4]1[CH:5]=[C:6]([C:11]2[O:12][C:13]3[CH:19]=[CH:18][C:17]([C:20]([F:23])([F:22])[F:21])=[CH:16][C:14]=3[N:15]=2)[C:7]([NH:27][CH2:24][CH2:25][CH3:26])=[CH:8][CH:9]=1)([O-:3])=[O:2]

Participants

3

Reactant 2

HCID 7852PropylamineHCID 218845112-(3-Nitro-6-fluorophenyl)-5-trifluoromethylbenzoxazole

Product 1

HCID 218844522-(3-Nitro-6-propylaminophenyl)-5-trifluoromethylbenzoxazole

Procedure

Prepared by the method of Example 54a), from 2-(3-nitro-6-fluorophenyl)-5-trifluoromethylbenzoxazole (218 mg, 0.8 mmol) and propylamine (328 μL, 4.0 mmol) the subtitle compound was obtained. The product was used directly in the next step without purification.

Sources & evidence

ORD record
ord-716874ddafe94509b9351849d8054af9
Source dataset
uspto-grants-2006_11
Patent number
US07138425B2

Reaction notes

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