HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Toluenesulfonic acid monohydrate → 2-(3-Nitro-6-fluorophenyl)-5-bromo-7-fluorobenzoxazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Toluenesulfonic acid monohydrate | HCID 521998 | — |
| Reactant | N-(2-Hydroxy-3-fluoro-5-bromophenyl)-2-fluoro-5-nitrobenzamide | HCID 21884296 | — |
| Product | 2-(3-Nitro-6-fluorophenyl)-5-bromo-7-fluorobenzoxazole | HCID 21884570 | — |
Reaction Steps
Prepared by the method of Example 15b), from N-(2-hydroxy-3-fluoro-5-bromophenyl)-2-fluoro-5-nitrobenzamide (858 mg, 2.3 mmol) and p-toluenesulfonic acid monohydrate (961 g, 5.1 mmol) the subtitle compound was obtained (475 mg, 58%). 1H NMR (DMSO) δ 8.91(m, 1H), 8.57(m, 1H), 8.06(s, 1H), 7.81(m, 3H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07138425B2 |
| Source dataset | uspto-grants-2006_11 |
| ORD ID | ord-ad7fff37a0564cd4a4258f749a48826f |
| Source note | uspto-grants-2006_11 |