Propylamine → 2-(3-Nitro-6-propylaminophenyl)-5-fluorobenzoxazole

HRID 722589Notes

Reaction equation

[N+:1]([C:4]1[CH:5]=[C:6]([C:11]2[O:12][C:13]3[CH:19]=[CH:18][C:17]([F:20])=[CH:16][C:14]=3[N:15]=2)[C:7](F)=[CH:8][CH:9]=1)([O-:3])=[O:2].[CH2:21]([NH2:24])[CH2:22][CH3:23]>>[N+:1]([C:4]1[CH:5]=[C:6]([C:11]2[O:12][C:13]3[CH:19]=[CH:18][C:17]([F:20])=[CH:16][C:14]=3[N:15]=2)[C:7]([NH:24][CH2:21][CH2:22][CH3:23])=[CH:8][CH:9]=1)([O-:3])=[O:2]

Participants

Reactant 2

HCID 7852Propylamine

HCID 218843392-(3-Nitro-6-fluorophenyl)-5-fluorobenzoxazole

Product 1

HCID 218844562-(3-Nitro-6-propylaminophenyl)-5-fluorobenzoxazole

Procedure

Prepared by the method of Example 54a), from 2-(3-nitro-6-fluorophenyl)-5-fluorobenzoxazole (221 mg, 0.8 mmol) and propylamine (328 μL, 4.0 mmol) the subtitle compound was obtained. The product was used directly in the next step without purification.

Sources & evidence

ORD record: ord-4b56c77c369a40a8b23d728901df1a4d
Source dataset: uspto-grants-2006_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07138425B2

Reaction notes

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