6-Amino-2,3-difluorophenol → N-(2-Hydroxy-3,4-difluorophenyl)-2-fluoro-5-nitrobenzamide

HRID 722591Notes

Reaction equation

HRID 722591 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[C:4]([F:9])[C:3]=1[OH:10].[F:11][C:12]1[CH:20]=[CH:19][C:18]([N+:21]([O-:23])=[O:22])=[CH:17][C:13]=1[C:14](Cl)=[O:15]>>[OH:10][C:3]1[C:4]([F:9])=[C:5]([F:8])[CH:6]=[CH:7][C:2]=1[NH:1][C:14](=[O:15])[C:13]1[CH:17]=[C:18]([N+:21]([O-:23])=[O:22])[CH:19]=[CH:20][C:12]=1[F:11]

Participants

3

Reactant 2

HCID 27784416-Amino-2,3-difluorophenolHCID 109765702-Fluoro-5-nitrobenzoyl chloride

Product 1

HCID 21884418N-(2-Hydroxy-3,4-difluorophenyl)-2-fluoro-5-nitrobenzamide

Procedure

Prepared by the method of Example 15a), from 2-amino-5,6-difluorophenol (334 mg, 2.3 mmol) and 2-fluoro-5-nitrobenzoyl chloride (468 mg, 2.3 mmol) the subtitle compound was obtained. The product was used directly in the next step without purification.

Sources & evidence

ORD record
ord-12e6546ed09946f798cbd255c15c496d
Source dataset
uspto-grants-2006_11
Patent number
US07138425B2

Reaction notes

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