p-Toluenesulfonic acid monohydrate → HCID 69585051, compound

HRID 722604Notes

Reaction equation

HRID 722604 reaction equation
[CH3:1][O:2][C:3](=[O:23])[C:4]1[CH:9]=[CH:8][C:7]([NH:10][C:11](=O)[C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([N+:18]([O-:20])=[O:19])[CH:13]=2)=[C:6]([OH:22])[CH:5]=1.O.C1(C)C=CC(S(O)(=O)=O)=CC=1>>[CH3:1][O:2][C:3]([C:4]1[CH:9]=[CH:8][C:7]2[N:10]=[C:11]([C:12]3[CH:17]=[CH:16][CH:15]=[C:14]([N+:18]([O-:20])=[O:19])[CH:13]=3)[O:22][C:6]=2[CH:5]=1)=[O:23]

Participants

3

Reactant 2

HCID 521998p-Toluenesulfonic acid monohydrateHCID 69585022HCID 69585022, compound

Product 1

HCID 69585051HCID 69585051, compound

Procedure

Prepared from the method of Example 15c), from 4-(3-nitrobenzamido)-3-hydroxybenzoic acid methyl ester (20 g, 63.0 mmol) and p-toluenesulfonic acid monohydrate (26.3 g, 138 mmol) the subtitle compound was obtained (3.05 g, 16%). 1H NMR (CDCl3) δ 9.13(t, 1H), 8.62(d, 1H), 8.44(dd, 1H), 8.33(s, 1H), 8.15(dd, 1H), 7.85(d, 1H), 7.77(t, 1H), 4.00(s, 3H).

Sources & evidence

ORD record
ord-81f540cfa9b4437694ecaaa36ce3a881
Source dataset
uspto-grants-2006_11
Patent number
US07138425B2

Reaction notes

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