p-Toluenesulfonic acid monohydrate → HCID 69585056, compound

HRID 722614Notes

Reaction equation

HRID 722614 reaction equation
[CH3:1][O:2][C:3](=[O:23])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([NH:10][C:11](=O)[C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([N+:18]([O-:20])=[O:19])[CH:13]=2)[C:5]=1[OH:22].O.C1(C)C=CC(S(O)(=O)=O)=CC=1>>[CH3:1][O:2][C:3]([C:4]1[C:5]2[O:22][C:11]([C:12]3[CH:17]=[CH:16][CH:15]=[C:14]([N+:18]([O-:20])=[O:19])[CH:13]=3)=[N:10][C:6]=2[CH:7]=[CH:8][CH:9]=1)=[O:23]

Participants

3

Reactant 2

HCID 521998p-Toluenesulfonic acid monohydrateHCID 69584933HCID 69584933, compound

Product 1

HCID 69585056HCID 69585056, compound

Procedure

Prepared by the method of Example 15c), from 3-(3-nitrobenzamido)-2-hydroxybenzoic acid methyl ester (1.00 mg, 3.16 mmol) and p-toluenesulfonic acid monohydrate (1.26 mg, 6.64 mmol) the subtitle compound was obtained (600 mg, 64%). 1H NMR (DMSO) δ 8.95(m, 1H), 8.7(m, 1H), 8.59(dd, 1H), 8.23(d, 1H), 8.05(m, 2H), 7.70(t, 1H).

Sources & evidence

ORD record
ord-fb0f46d9104a4e7fa304161d34859f23
Source dataset
uspto-grants-2006_11
Patent number
US07138425B2

Reaction notes

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