2-(3-Nitro-4-methoxyphenyl)-5-(2-benzothiophenyl)benzoxazole → HCID 21884573, compound

HRID 722625Notes

Reaction equation

HRID 722625 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]([C:12]2[O:13][C:14]3[CH:20]=[CH:19][C:18]([C:21]4[S:22][C:23]5[CH:29]=[CH:28][CH:27]=[CH:26][C:24]=5[CH:25]=4)=[CH:17][C:15]=3[N:16]=2)[CH:7]=[CH:8][C:9]=1[O:10][CH3:11])([O-])=O>[Pd].O1CCOCC1>[NH2:1][C:4]1[CH:5]=[C:6]([C:12]2[O:13][C:14]3[CH:20]=[CH:19][C:18]([C:21]4[S:22][C:23]5[CH:29]=[CH:28][CH:27]=[CH:26][C:24]=5[CH:25]=4)=[CH:17][C:15]=3[N:16]=2)[CH:7]=[CH:8][C:9]=1[O:10][CH3:11]

Participants

4

Reactant 1

HCID 218845482-(3-Nitro-4-methoxyphenyl)-5-(2-benzothiophenyl)benzoxazole

Product 1

HCID 21884573HCID 21884573, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 312751,4-DioxaneSolvent

Procedure

Prepared by the method of Example 15e), from 2-(3-nitro-4-methoxyphenyl)-5-(2-benzothiophenyl)benzoxazole (200 mg, 0.50 mmol) and palladium on carbon (10%) (10 mg) in dioxane (10 ml), the subtitle compound was obtained.(40 mg, 86%). MS 373.2 m/z (M+H)+.

Sources & evidence

ORD record
ord-de62845d412c4d569d189cb01c1747f2
Source dataset
uspto-grants-2006_11
Patent number
US07138425B2

Reaction notes

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