Benzo(B)Thiophene-2-Boronic Acid → HCID 21884571, compound

HRID 722636Notes

Reaction equation

HRID 722636 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]([C:12]2[O:13][C:14]3[CH:20]=[CH:19][C:18](Br)=[CH:17][C:15]=3[N:16]=2)[C:7]([O:10][CH3:11])=[CH:8][CH:9]=1)([O-:3])=[O:2].[S:22]1[C:26]2[CH:27]=[CH:28][CH:29]=[CH:30][C:25]=2[CH:24]=[C:23]1B(O)O>>[N+:1]([C:4]1[CH:5]=[C:6]([C:12]2[O:13][C:14]3[CH:20]=[CH:19][C:18]([C:23]4[S:22][C:26]5[CH:27]=[CH:28][CH:29]=[CH:30][C:25]=5[CH:24]=4)=[CH:17][C:15]=3[N:16]=2)[C:7]([O:10][CH3:11])=[CH:8][CH:9]=1)([O-:3])=[O:2]

Participants

3

Reactant 2

HCID 2359Benzo(B)Thiophene-2-Boronic AcidHCID 21884587HCID 21884587, compound

Product 1

HCID 21884571HCID 21884571, compound

Procedure

Prepared by the method of Example 15d), from 2-(3-nitro-6-methoxyphenyl)-5-bromobenzoxazole (400 mg, 1.14 mmol) and benzothiophene-2-boronic acid (306 mg, 1.71 mmol) the subtitle compound was obtained (569 mg, 123%). The product was used directly in the next step without purification.

Sources & evidence

ORD record
ord-255b0c8539eb4db08b4c5b9cd3843eae
Source dataset
uspto-grants-2006_11
Patent number
US07138425B2

Reaction notes

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