Propylamine → 2-(2-Propylamino-5-nitrophenyl)-5-(2-benzofuranyl)benzoxazole

HRID 722653Notes

Reaction equation

HRID 722653 reaction equation
F[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][C:3]=1[C:11]1[O:12][C:13]2[CH:19]=[CH:18][C:17]([C:20]3[O:21][C:22]4[CH:28]=[CH:27][CH:26]=[CH:25][C:23]=4[CH:24]=3)=[CH:16][C:14]=2[N:15]=1.[CH2:29]([NH2:32])[CH2:30][CH3:31]>>[CH2:29]([NH:32][C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][C:3]=1[C:11]1[O:12][C:13]2[CH:19]=[CH:18][C:17]([C:20]3[O:21][C:22]4[CH:28]=[CH:27][CH:26]=[CH:25][C:23]=4[CH:24]=3)=[CH:16][C:14]=2[N:15]=1)[CH2:30][CH3:31]

Participants

3

Reactant 2

HCID 7852PropylamineHCID 218842952-(2-Fluoro-5-nitrophenyl)-5-(2-benzofuranyl)benzoxazole

Product 1

HCID 218843282-(2-Propylamino-5-nitrophenyl)-5-(2-benzofuranyl)benzoxazole

Procedure

Prepared by the method of Example 54a), from 2-(2-fluoro-5-nitrophenyl)-5-(2-benzofuranyl)benzoxazole (200 mg, 0.53 mmol), and propylamine (3 ml) the subtitle compound was obtained (199 mg, 91%). The product was used directly in the next step without purification.

Sources & evidence

ORD record
ord-76d43d79a2ce4dba906c8d017b2a5e5e
Source dataset
uspto-grants-2006_11
Patent number
US07138425B2

Reaction notes

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